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Human papillomavirus prevalence in women attending routine cervical screening in South Wales, UK: a cross-sectional study

Hibbitts, Samantha Jayne, Jones, Joanne, Powell, N., Dallimore, N., McRea, J., Beer, H., Tristram, Amanda Jane, Fielder, H. and Fiander, Alison Nina 2008. Human papillomavirus prevalence in women attending routine cervical screening in South Wales, UK: a cross-sectional study. British Journal of Cancer 99 (11) , pp. 1929-1933. 10.1038/sj.bjc.6604748

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In this cross-sectional population-based study we determine human papillomavirus (HPV) prevalence in South Wales to provide comprehensive baseline data for future assessment of the impact of prophylactic HPV vaccination and to help inform future screening strategies. Liquid-based cytology samples from women attending routine cervical screening were collected (n=10 000: mean age 38 years, 93% cytology negative, and 64.8% from the 50% least deprived LSOA according to social deprivation score (SDS)). High-Risk (HR) and Low-Risk HPV screening was performed using HPV PCR-EIA with genotyping of HR positives and data correlated with age, SDS and cytology. Overall HPV prevalence was 13.5% (9.3% age standardised) and the most frequent HR types were HPV 16, 31, 18 and 58. In HR HPV-positive cases 42.4% had a single HR type and they were predominant in women with severe cytological abnormalities. Here, 66% of all HR HPV cases were in women aged 30 years of age or less and SDS had no significant effect on HPV status. HPV prevalence increased significantly with degree of dyskarosis from 7% in cytology negative samples to 80% in samples with severe cytological abnormalities (P-value <0.0001). Overall, 46% of HR HPV cases were positive for the two HR types targeted by the prophylactic vaccines (HPV 16 and HPV 18). The data presented represents the largest type-specific investigation of HPV prevalence in an unselected UK population.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: HPV prevalence; cervical cancer; prophylactic HPV vaccine ‘Cervarix™'; single and multiple HR cases
Publisher: Nature Publishing Group
ISSN: 0007-0920
Last Modified: 06 Jun 2020 16:10

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