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Impact of meningococcal serogroup C conjugate vaccines on carriage and herd immunity

Maiden, Martin C. J., Ibarz-Pavón, Ana Belén, Urwin, Rachel, Gray, Stephen J., Andrews, Nicholas J., Clarke, Stuart C., Walker, A. Mark, Evans, Meirion Rhys, Kroll, J. Simon, Neal, Keith R., Ala'Aldeen, Dlawer A. A., Crook, Derrick W., Cann, Kathryn, Harrison, Sarah, Cunningham, Richard, Baxter, David, Kaczmarski, Edward, MacLennan, Jenny, Cameron, J. Claire and Stuart, James M. 2008. Impact of meningococcal serogroup C conjugate vaccines on carriage and herd immunity. Journal of Infectious Diseases 197 (5) , pp. 737-743. 10.1086/527401

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Abstract

Background. In 1999, meningococcal serogroup C conjugate (MCC) vaccines were introduced in the United Kingdom for those under 19 years of age. The impact of this intervention on asymptomatic carriage of meningococci was investigated to establish whether serogroup replacement or protection by herd immunity occurred. Methods. Multicenter surveys of carriage were conducted during vaccine introduction and on 2 successive years, resulting in a total of 48,309 samples, from which 8599 meningococci were isolated and characterized by genotyping and phenotyping. Results. A reduction in serogroup C carriage (rate ratio, 0.19) was observed that lasted at least 2 years with no evidence of serogroup replacement. Vaccine efficacy against carriage was 75%, and vaccination had a disproportionate impact on the carriage of sequence type (ST)-11 complex serogroup C meningococci that (rate ratio, 0.06); these meningococci also exhibited high rates of capsule expression. Conclusions. The impact of vaccination with MCC vaccine on the prevalence of carriage of group C meningococci was consistent with herd immunity. The high impact on the carriage of ST-11 complex serogroup C could be attributed to high levels of capsule expression. High vaccine efficacy against disease in young children, who were not protected long-term by the schedule initially used, is attributed to the high vaccine efficacy against carriage in older age groups.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Publisher: Oxford University Press
ISSN: 1537-6613
Last Modified: 21 Aug 2019 02:30
URI: http://orca-mwe.cf.ac.uk/id/eprint/24983

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