Molluscum contagiosum virus

Bugert, Joachim Jakob ORCID: https://orcid.org/0000-0002-0556-3211 2008. Molluscum contagiosum virus. Mahy, B. W. J and Van Regenmortel, Marc H. V., eds. Encyclopedia of Virology 3rd ed, Amsterdam: Elsevier, pp. 319-324. (10.1016/B978-012374410-4.00444-1)

Full text not available from this repository.

Abstract

Molluscum contagiosum virus (MCV) is the causative agent of benign wart-like skin tumors limited to the human epidermis. This skin condition is known as molluscum contagiosum (MC) and is histologically classified as an acanthoma. MC has a worldwide distribution, is most common in preadolescent children, and occurs frequently in overcrowded populations with reduced hygenic standards. With a mean incidence of 0.1–5% MC is, after the eradication of smallpox, the only clinically relevant poxvirus infection of humans. MCV is a member of the family Poxviridae and the type species of the genus Molluscipoxvirus. It has a double-stranded DNA genome of 190 289 bp (GenBank accession U60315: MCV type 1/80) encoding 182 nonoverlapping open reading frames. About 20% of the gene complement shares homologies to other poxvirus proteins. Among the few unique MCV genes with known functions are an apoptosis inhibitor (vFLIP), an IL18-binding protein, a soluble IL8 antagonist, and an Hrs-binding protein. MCV can be readily diagnosed clinically but may be confused with early-stage orthopoxvirus and herpesvirus lesions or other hyperproliferative skin conditions. Other viral agents can be excluded by electron microscopy and polymerase chain reaction (PCR). Treatment consists of topical application of salicylic acid or removal by curettage.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QR Microbiology Q Science > QR Microbiology > QR355 Virology R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Uncontrolled Keywords:	Benign skin tumor ; Crocodilepox virus ; Eczema molluscum ; Epidermal hyperproliferation ; Immune evasion ; Molluscum contagiosum virus ; Monophylitic poxvirus (possible); Parapoxviruses ; Persistent infection
Publisher:	Elsevier
ISBN:	9780123739353
Related URLs:	http://www.elsevier.com/wps/find/bookdes...
Last Modified:	19 Oct 2022 10:36
URI:	https://orca.cardiff.ac.uk/id/eprint/24962

Citation Data

Cited 7 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item