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Effects of surgery on ischaemic mitral regurgitation: A prospective multicenter registry (SIMRAM registry)

Lancellotti, Patrizio, Donal, Erwan, Cosyns, Bernard, Van Camp, Guy, Monin, Jean-Luc, Brochet, Eric, Berrebi, Alain, Pibarot, Philippe, Chauvel, Christophe, Hassager, Christian, Tumminello, Gabriele, Tribouilloy, Christophe, Lafitte, Stephane, Fraser, Alan Gordon, Derumeaux, Genevieve, Athanassopoulos, George, Jeroan, Bax and Pierard, Luc A. 2007. Effects of surgery on ischaemic mitral regurgitation: A prospective multicenter registry (SIMRAM registry). European Journal of Echocardiography 9 (1) , pp. 26-30. 10.1016/j.euje.2006.12.009

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Aims Functional ischaemic mitral regurgitation (IMR) is common in patients with ischaemic left ventricular dysfunction undergoing coronary artery bypass surgery. Although the presence of IMR negatively affects prognosis, the additional benefit of valve repair is debated, particularly with mild IMR at rest. Exercise echocardiography may help identify a subset of patients at higher risk of cardiovascular events by revealing the dynamic component of IMR. Methods A large prospective, multicentre, non-randomized registry is designed to evaluate the effects of surgery on IMR at rest and on its dynamic component at exercise (z). SIMRAM will enrol approximately 550 patients with IMR in up to 17 centres with clinical and exercise follow-up for 1 year. Three sets of outcomes will be prospectively assessed and several hypotheses will be tested including determinants of adverse outcome and progressive left ventricular remodeling, efficacy of treatment and role of ischaemia on the dynamic consequences of IMR. Enrolment began in November 2006 and is expected to end by early 2008.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RD Surgery
Uncontrolled Keywords: Mitral regurgitation; Surgery; Exercise; Echocardiography
Publisher: Oxford University Press
ISSN: 1525-2167
Last Modified: 04 Jun 2017 03:41

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