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Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI study

Azuma, Rayna, Daly, Eileen M., Campbell, Linda E., Stevens, Angela F., Deeley, Quinton, Giampietro, Vincent, Brammer, Michael J., Glaser, Beate, Ambery, Fiona Z., Morris, Robin G., Williams, Steven C. R., Owen, Michael John, Murphy, Declan G. M. and Murphy, Kieran C. 2009. Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI study. Journal of Neurodevelopmental Disorders 1 (1) , pp. 46-60. 10.1007/s11689-009-9008-9

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Abstract

22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with a microdeletion of chromosome 22q11. In addition to high rates of neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder, children with 22q11DS have a specific neuropsychological profile with particular deficits in visuospatial and working memory. However, the neurobiological substrate underlying these deficits is poorly understood. We investigated brain function during a visuospatial working memory (SWM) task in eight children with 22q11DS and 13 healthy controls, using fMRI. Both groups showed task-related activation in dorsolateral prefrontal cortex (DLPFC) and bilateral parietal association cortices. Controls activated parietal and occipital regions significantly more than those with 22q11DS but there was no significant between-group difference in DLPFC. In addition, while controls had a significant age-related increase in the activation of posterior brain regions and an age-related decrease in anterior regions, the 22q11DS children showed the opposite pattern. Genetically determined differences in the development of specific brain systems may underpin the cognitive deficits in 22q11DS, and may contribute to the later development of neuropsychiatric disorders.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Velo-cardio-facial syndrome, 22q11.2 deletion syndrome, Spatial working memory, fMRI, Ageing, Schizophrenia
Publisher: Springer
ISSN: 1866-1947
Last Modified: 20 Oct 2017 09:59
URI: http://orca-mwe.cf.ac.uk/id/eprint/23634

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