Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Protein kinase C-dependent phosphorylation of Borna disease virus P protein is required for efficient viral spread

Schmid, Sonja, Metz, Philippe, Prat, Christine Marie Alexine, Gonzalez-Dunia, Daniel and Schwemmle, Martin 2010. Protein kinase C-dependent phosphorylation of Borna disease virus P protein is required for efficient viral spread. Archives of Virology 155 (5) , pp. 789-793. 10.1007/s00705-010-0645-9

Full text not available from this repository.

Abstract

Mutational analysis of the phosphate acceptor sites of the Borna disease virus (BDV) phosphoprotein (P) has suggested a role of phosphorylation for viral spread. However, the studied mutant viruses also had two amino acid exchanges in the X protein, because the reading frames of P and X overlap. To determine the relative contribution of P and X to viral attenuation, we studied a P variant with serine-to-leucine substitutions (P(S26L,S28L)) in which the wild-type X sequence was conserved. Viral spread of rBDV-P(S26L,S28L) was impaired in human oligodendroglioma cells and in adult rats. Thus, BDV-P phosphorylation contributes to efficient viral dissemination.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Springer Verlag
ISSN: 0304-8608
Last Modified: 13 Oct 2016 16:00
URI: http://orca-mwe.cf.ac.uk/id/eprint/23188

Citation Data

Cited 12 times in Google Scholar. View in Google Scholar

Cited 3 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item