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Sulfation patterns of keratan sulfate in different macular corneal dystrophy immunophenotypes using three different probes [Letter]

Saito, T., Nishida, K., Nakayama, J., Akama, T. O., Fukuda, M. N., Watanabe, K., Quantock, Andrew James, Maeda, N., Watanabe, H. and Tano, Y. 2008. Sulfation patterns of keratan sulfate in different macular corneal dystrophy immunophenotypes using three different probes [Letter]. British Journal of Ophthalmology 92 (10) , pp. 1434-1436. 10.1136/bjo.2008.139527

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Abstract

Macular corneal dystrophy (MCD) is subdivided into three immunophenotypes, MCD types I, IA and II, based on the reactivity of serum and corneal tissue to an antibody that recognises sulfated keratan sulfate (KS).1 In MCD type I (MCD-I), antigenic KS is undetectable in both serum and cornea, while in MCD-II it is present at normal or subnormal levels in serum, and is evident immunohistochemically in the corneal stroma. In MCD-IA, antigenic KS is absent from serum and extracellular stromal matrix, but is detected in keratocytes. Mutations of the carbohydrate sulfotransferase gene, CHST6, have been identified as causative for MCD.2 This study investigated the distribution of differentially sulfated KS in cornea in the three main MCD immunophenotypes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Publisher: BMJ Publishing Group
ISSN: 0007-1161
Last Modified: 04 Jun 2017 03:35
URI: http://orca-mwe.cf.ac.uk/id/eprint/23102

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