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Use of intraoperative insulin assay for the localisation of insulinoma

Scott-Coombes, David, Eatock, Fiona, Henley, Robert and Luzio, Stephen Denis 2009. Use of intraoperative insulin assay for the localisation of insulinoma. World Journal of Surgery 33 (5) , pp. 969-971. 10.1007/s00268-009-9946-0

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Background The curative treatment for patients with insulinoma is the surgical removal of the tumour; however, these tumours are small and therefore their preoperative localisation using ultrasound and CT scans may be difficult. Methods Intraoperative serum insulin measurements were used as an aid to the surgical management of seven unselected and consecutive presentations of insulinoma. Results In six of the seven cases we were able to demonstrate an increase in the peripheral serum insulin concentration between 3 and 5 min after manual examination of the tumour. In addition, there was a 50% decrease in concentration 10 min after removal of the tumour. Conclusions We believe that intraoperative insulin measurements are of use in demonstrating the functionality of tumours localised by intraoperative ultrasound and surgical examination. In addition, they act as an indicator of the completeness of surgery post tumour excision.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Postgraduate Medical and Dental Education
Subjects: R Medicine > R Medicine (General)
Publisher: Springer
ISSN: 0364-2313
Last Modified: 04 Jun 2017 03:35

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