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HTRA proteases: regulated proteolysis in protein quality control

Clausen, Tim, Kaiser, Markus, Huber, Robert and Ehrmann, Michael 2011. HTRA proteases: regulated proteolysis in protein quality control. Nature Reviews Molecular Cell Biology 12 (3) , pp. 152-162. 10.1038/nrm3065

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Controlled proteolysis underlies a vast diversity of protective and regulatory processes that are of key importance to cell fate. The unique molecular architecture of the widely conserved high temperature requirement A (HTRA) proteases has evolved to mediate critical aspects of ATP-independent protein quality control. The simple combination of a classic Ser protease domain and a carboxy-terminal peptide-binding domain produces cellular factors of remarkable structural and functional plasticity that allow cells to rapidly respond to the presence of misfolded or mislocalized polypeptides.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Publisher: Nature Publishing Group
ISSN: 1471-0072
Last Modified: 24 Jun 2017 08:51

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