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Gene copy number variation in schizophrenia

Sutrala, Smitha R., Norton, Nadine, Williams, Nigel Melville and Buckland, Paul Robert 2008. Gene copy number variation in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B (5) , pp. 606-611. 10.1002/ajmg.b.30645

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Abstract

Recent reports have highlighted the possibility that gene copy number variations play a role in the development of complex disorders and have suggested that some variations are very common in schizophrenic patients. We have carried out a comparative genomic hybridization screen using oligonucleotide probes of 891 candidate genes to look for very common copy number variance in schizophrenic patients. In addition we have developed a new approach for the detection and validation of putative copy number variation based upon established methods of allele quantification by DNA pooling and have used it to study 15 major candidates including dysbindin (DTNBP1), neuregulin (NRG1), RGS4 and DISC1. With the exception of positive control sequences, no copy number variations were found for any of the genes in any samples by the use of either technique. Our data for the genes studied are in line with the known existence and frequency of CNVs as reported by recent large scale studies and suggest that gene copy number variations are not more common in schizophrenics than controls, although large ethnic differences cannot be excluded.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: copy number variation; allelic expression; SnaPshot; schizophrenia
Publisher: Wiley-Blackwell
ISSN: 1552-4841
Last Modified: 07 Nov 2017 02:27
URI: http://orca-mwe.cf.ac.uk/id/eprint/21969

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