Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Synthesis and CYP24 inhibitory activity of 2-substituted-3,4-dihydro-2H-naphthalen-1-one (tetralone) derivatives

Yee, Sook Wah and Simons, Claire 2004. Synthesis and CYP24 inhibitory activity of 2-substituted-3,4-dihydro-2H-naphthalen-1-one (tetralone) derivatives. Bioorganic & Medicinal Chemistry Letters 14 (22) , pp. 5651-5654.

Full text not available from this repository.

Abstract

The synthesis of novel 2-benzyl- and 2-benzylidene-3,4-dihydro-2H-naphthalen-1-one (tetralone) derivatives and their inhibitoryactivity versus kidney mitochondrial 25-hydroxyvitamin D3 24-hydroxylase (CYP24) is described. The 2-benzylidenetetralone derivatives were found to be very weak inhibitors (IC50 20 >100 μM), whereas the 2-benzyltetralone derivatives showed promising inhibitoryactivity (IC50 0.9 μM for the most active derivative) compared with ketoconazole (IC50 20 μM).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Additional Information: Miss Sook Wah Yee would like to acknowledge the ORS Awards Scheme for a United Kingdom Scholarship.
Last Modified: 04 Jun 2017 03:20
URI: http://orca-mwe.cf.ac.uk/id/eprint/19827

Citation Data

Cited 20 times in Google Scholar. View in Google Scholar

Cited 27 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item