The type II transmembrane serine protease, matriptase-2: possible links to cancer ?

Sanders, Andrew James ORCID: https://orcid.org/0000-0002-7997-5286, Webb, Siobhan L., Parr, Christian, Mason, Malcolm David ORCID: https://orcid.org/0000-0003-1505-2869 and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2010. The type II transmembrane serine protease, matriptase-2: possible links to cancer ? Anti-Cancer Agents in Medicinal Chemistry 10 (1) , pp. 64-69.

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Abstract

Matriptase-2 is a newly identified member of the Type II Transmembrane Serine Protease (TTSP) family. The expression profile of many members of this family of proteases is frequently altered in cancerous cells and tissues and a number of TTSPs have been linked to cancer progression and development. Matriptase-2 is structurally similar to matriptase-1, a TTSP which has gained recent interest due to its potential to enhance the aggressive nature of cancer cells and its links with a variety of human cancers. Recently, matriptase- 2 has been functionally linked to the regulation of iron metabolism; however, there is also evidence to suggest that, as with other members of the TTSPs, matriptase-2 may have a role in cancer development and progression. This article reviews the current literature on matriptase-2, together with its potential roles in physiological and disease states particularly focusing on cancer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Matriptase-2, TTSP, prostate cancer, breast cancer, TMPRSS 6
Publisher:	Bentham Science
ISSN:	1875-5992
Last Modified:	19 Oct 2022 08:37
URI:	https://orca.cardiff.ac.uk/id/eprint/18432

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