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Retrograde transneuronal transport properties of fragment C of tetanus toxin

Manning, K. A., Erichsen, Jonathan Thor and Evinger, C. 1990. Retrograde transneuronal transport properties of fragment C of tetanus toxin. Neuroscience 34 (1) , pp. 251-263. 10.1016/0306-4522(90)90319-Y

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Abstract

The atoxic fragmentC of tetanustoxin reliably undergoes retrograde direct and transneuronaltransport, but the full extent of its transport capabilities has not been examined. The primary visual pathways provide an excellent system for investigating, for the first time, the possibility of anterograde direct and transneuronaltransport of fragmentC. Following injection into the eye of the rat and rabbit, fragmentC, localized with a monoclonal antibody, underwent anterograde direct transport to all retinorecipient areas. From these areas, fragmentC exhibited retrogradetransneuronaltransport, strongly and reliably labeling regions that project to retinorecipient areas, including layers V and VI of visual cortex, the parabigeminal nucleus, the suprageniculate nucleus, and the reticular thalamus. In contrast, the absence of fragmentC in regions receiving only input from, but not projecting to, retinorecipient areas, most notably layer IV of visual cortex, provides strong evidence for the lack of anterograde transneuronaltransport. Thus, while fragmentC can be induced to undergo anterograde direct transport by injection into the eye, it exhibits only retrogradetransneuronaltransport. These characteristics suggest that fragmentC of tetanustoxin is a consistent and reliable retrogradetransneuronal marker for the elucidation of central nervous pathways.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Elsevier
ISSN: 0306-4522
Last Modified: 04 Jun 2017 03:11
URI: http://orca-mwe.cf.ac.uk/id/eprint/17904

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