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PSS15 Changes in health related utility among adults with atopic dermatitis treated with tacrolimus ointment compared to a standard corticosteroid regimen [Abstract]

Poole, Christopher David, Chambers, C., Allsopp, Richard and Currie, Craig John 2009. PSS15 Changes in health related utility among adults with atopic dermatitis treated with tacrolimus ointment compared to a standard corticosteroid regimen [Abstract]. Value in Health 12 (3) , A77. 10.1111/j.1524-4733.2009.00537_2.x

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Abstract

OBJECTIVES: Long-term treatment with 0.1% tacrolimus ointment (TO) has been demonstrated as well-tolerated and effective for the treatment of atopic dermatitis (AD) but its impact on utility has not been reported. The purpose of this study was to estimate utility changes associated with TO versus a standard corticosteroid regimen (CR) in the treatment of moderate-to-severe AD in adults. METHODS: Data were analysed from a double-blind RCT. Patients were treated with either TO applied twice-daily for six months to the head, neck, trunk and extremities, or alternatively 0.1% hydrocortisone butyrate ointment administered to the trunk and extremities and 1% hydrocortisone acetate ointment applied to the head and neck. Health-related utility (EQ5Dindex) was estimated by Monte Carlo simulation from SF12 responses collected during the clinical trial by applying a published mapping algorithm. RESULTS: Data were available for 972 patients (intention-to-treat), 46% of whom were male with a mean age of 32 years (SD 12). At baseline the mean EQ5Dindex was similar between both arms (0.721 vs. 0.730; p = 0.461, for CR vs. TO, respectively). After 28 days the mean EQ5Dindex improved in both treatment arms (0.820 vs. 0.849; p = 0.004, respectively). The incremental EQ5Dindex between the treatment arms increased as the trial progressed. At 6-months subjects treated with TO had signifi cantly higher utility than CR-treated subjects (0.789 vs. 0.831; p = 0.001; respectively). CONCLUSIONS: Patients with AD had considerable decrement in health-related utility at baseline. Treatment with 0.1% tacrolimus ointment was associated with a consistently improved, clinically-signifi cant, incremental increase in health-related utility compared to the corticosteroid regimen, increasing over a six month period.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RL Dermatology
Additional Information: Poster abstract for ISPOR fourteenth annual international meeting research abstracts
Publisher: Wiley-Blackwell
ISSN: 1098-3015
Last Modified: 04 Jun 2017 03:11
URI: http://orca-mwe.cf.ac.uk/id/eprint/17835

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