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KAI-1/CD82, The molecule and clinical implication in cancer and cancer metastasis

Malik, Fraz Arshad, Sanders, Andrew James and Jiang, Wen Guo 2009. KAI-1/CD82, The molecule and clinical implication in cancer and cancer metastasis. Histology and Histopathology 24 (4) , pp. 519-530.

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Abstract

CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. In recent years apart from its significant involvement in the suppression of secondary tumours it has also been observed that KAI1/CD82 plays a vital role in virus binding and its entry inside the cell. Decreased expression of KAI1/CD82 molecule results in aggravating cancer progression. Altered expression levels of KAI1/CD82 molecule in different types of human cancer have been implicated as having prognostic value and linking to the long term survival of the patients. Increased level of KAI1/CD82 also results in the suppression of secondary tumour growth. Increased expression of this molecule results in reduced cell invasion and cell migration due to endocytosis of epidermal growth factor receptors (EGFR). Thus, KAI-1/CD82 is a pivotal molecule in the regulation of cancer cells' behaviour and has important clinical and therapeutic implications in cancer.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: KAI-1, CD82, cancer, cancer metastasis, invasion
Publisher: Thomson Scientific
ISSN: 0213-3911
Last Modified: 04 Jun 2017 03:11
URI: http://orca-mwe.cf.ac.uk/id/eprint/17828

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