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A cost per live birth comparison of HMG and rFSH randomized trials

Connolly, Mark, De Vrieze, Kathleen, Ombelet, Willem, Schneider, Dirk and Currie, Craig J. 2008. A cost per live birth comparison of HMG and rFSH randomized trials. Reproductive BioMedicine Online 17 (6) , pp. 756-763. 10.1016/S1472-6483(10)60402-6

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To help inform healthcare treatment practices and funding decisions, an economic evaluation was conducted to compare the two leading gonadotrophins used for IVF in Belgium. Based on the results of a recently published meta-analysis, a simulated decision tree model was constructed with four states: (i) fresh cycle, (ii) cryopreserved cycle, (iii) live birth and (iv) treatment withdrawal. Gonadotrophin costs were based on highly purified human menopausal gonadotrophin (HP-HMG; Menopur) and recombinant FSH (rFSH) alpha (Gonal-F). After one fresh and one cryopreserved cycle the average treatment cost with HP-HMG was lower than with rFSH (HP-HMG €3635; rFSH €4103). The average cost saving per person started on HP-HMG when compared with rFSH was €468. Additionally, the average costs per live birth of HP-HMG and rFSH were found to be significantly different: HP-HMG €9996; rFSH €13,009 (P < 0.0001). HP-HMG remained cost-saving even after key parameters in the model were varied in the probabilistic sensitivity analysis. Treatment with HP-HMG was found to be the dominant treatment strategy in IVF because of improved live birth rates and lower costs. Within a fixed healthcare budget, the cost-savings achieved using HP-HMG would allow for the delivery of additional IVF cycles.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RG Gynecology and obstetrics
Uncontrolled Keywords: Belgium; cost–effectiveness analysis; cost savings; conomic evaluation; gonadotrophins; IVF
Publisher: Elsevier
ISSN: 1472-6483
Last Modified: 04 Jun 2017 03:10

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