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Growth factor signalling networks in breast cancer and resistance to endocrine agents: new therapeutic strategies

Nicholson, Robert Ian, Hutcheson, Iain Robert, Britton, David James, Knowlden, Janice Mary, Jones, Helen E., Harper, Maureen Elaine, Hiscox, Stephen Edward, Barrow, Denise and Gee, Julia Margaret Wendy 2005. Growth factor signalling networks in breast cancer and resistance to endocrine agents: new therapeutic strategies. The Journal of Steroid Biochemistry and Molecular Biology 93 (2-5) , pp. 257-262. 10.1016/j.jsbmb.2004.12.006

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Abstract

Recent evidence demonstrates that growth factor networks are highly interactive with the estrogen receptor (ER) in the control of breast cancer growth and development. As such, tumor responses to anti-hormones are likely to be a composite of the ER and growth factor inhibitory activity of these agents, with alterations/aberrations in growth factor signalling providing a mechanism for the development of anti-hormone resistance. In this light, the current article focuses on illustrating the relationship between growth factor signalling and anti-hormone failure in our in-house tumor models of breast cancer and describes how we are now beginning to successfully target their actions to improve the effects of anti-hormonal drugs and to block aggressive disease progression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Biosciences
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Breast cancer; EGFR; HER2; IGF-IR; Tamoxifen; Gefitinib; Endocrine and gefitinib resistance
Additional Information: Proceedings of the 16th International Symposium of The Journal of Steroid Biochemistry and Molecular Biology. Edited by G. Daxenbichler, M. Hubalek, G.S. Chetrite and J.R. Pasqualini.
Publisher: Elsevier
ISSN: 0960-0760
Last Modified: 05 Aug 2018 02:13
URI: http://orca-mwe.cf.ac.uk/id/eprint/17198

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