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Modulation of oestrogen action by receptor gene inhibition

Madden, Tracie-Ann, Barrow, Denise, McClelland, Richard Andrew, Gee, Julia Margaret Wendy and Nicholson, Robert Ian 2000. Modulation of oestrogen action by receptor gene inhibition. European Journal of Cancer 36 (S4) , pp. 34-35. 10.1016/S0959-8049(00)00216-1

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Abstract

Selective oestrogen receptor downregulators (SERDs) are a class of highly effective steroidal antitumour agents that reduce cellular levels of the oestrogen receptor (ER). In this study, we compared the efficacy by which three novel molecular approaches: (1) antisense oligonucleotides; (2) antisense RNA; and (3) dominant negative mutants are able to act as SERDs. Using transient and, where appropriate, stable gene transfection experiments we found that constitutive overexpression of ER antisense RNA and a hormone-binding domain compromised dominant-negative ER mutant (DNER-1), were most effective at downregulating ER expression and/or activity in vitro.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Breast cancer; Oestrogen receptor; Antisense; Dominant-negative; Gene inhibition
Publisher: Elsevier
ISSN: 0014-2964
Last Modified: 12 Jun 2019 02:10
URI: http://orca-mwe.cf.ac.uk/id/eprint/17173

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