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Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy

McClelland, Richard Andrew, Manning, D. L., Gee, Julia Margaret Wendy, Willsher, P., Robertson, J. F. R., Ellis, I. O., Blamey, R. W. and Nicholson, Robert Ian 1998. Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy. British Journal of Cancer 77 (10) , pp. 1653-1656. 10.1038/bjc.1998.457

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Abstract

Northern hybridization analyses of the oestrogen-inducible mRNAs pLIV1 and pS2 were compared with oestrogen receptor (ER) immunocytochemistry assessments in 40 untreated primary or early recurrent breast tumours. Significant associations were observed between pLIV1/ER (P < 0.03), pS2/ER (P < 0.001) and pLIV1/pS2 (P < 0.04) status. After disease recurrence, patients were treated with assessable courses of endocrine therapies. Positive pLIV1, pS2 and ER statuses in primary disease were consequently found to be predictive of endocrine responsiveness in the secondary lesions (P < 0.03, P < 0.02, P < 0.005 respectively). However, despite these associations, a number of pLIV1- and/or pS2-positive tumours failed to respond to therapy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
Publisher: Nature Publishing Group
ISSN: 0007-0920
Last Modified: 12 Jun 2019 02:10
URI: http://orca-mwe.cf.ac.uk/id/eprint/17155

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