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Epidermal growth factor receptor expression in breast cancer: Association with response to endocrine therapy

Nicholson, Robert Ian, McClelland, Richard Andrew, Gee, Julia Margaret Wendy, Manning, David L., Cannon, P., Robertson, J. F. R., Ellis, I. O. and Blamey, R. W. 1994. Epidermal growth factor receptor expression in breast cancer: Association with response to endocrine therapy. Breast Cancer Research and Treatment 29 (1) , pp. 117-125. 10.1007/BF00666187

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106 previously untreated breast cancer patients have been immunohistochemically analysed for EGF-R, ER, Ki67, and c-erbB-2 product. All patients received assessable endocrine therapy following disease progression. Significant associations were observed between EGF-R and ER (inverse) and Ki67 (direct). No association was observed between EGF-R and the c-erbB-2 product. EGF-R expression was significantly associated with the loss of endocrine sensitivity in breast cancer. This was observed in both ER positive and negative disease. In ER positive breast cancers, EGF-R expression had no significant influence on the quality of tumour remissions. Further sub-classification of the ER/EGF-R data by Ki67 immunostaining showed that in ER+/EGF-R- disease, increasing proportions of Ki67 positive cells were associated with a decline in the numbers of women experiencing good quality tumour remissions. A similar trend was also observed in ER+/EGF-R+ tumours. The presence of c-erbB-2 protein product did not influence endocrine sensitivity in any of the ER/EGF-R sub-groups.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: breast cancer - endocrine therapy - epidermal growth factor receptor - estrogen receptor - Ki67 - c-erbB-2
Publisher: Springer Verlag
ISSN: 0167-6806
Last Modified: 12 Jun 2019 02:09

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