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Transforming growth factor-α and endocrine sensitivity in breast cancer

Nicholson, Robert Ian, McClelland, Richard Andrew, Gee, Julia Margaret Wendy, Manning, D. L., Cannon, P., Robertson, J. F. R., Ellis, I. O. and Blamey, R. W. 1994. Transforming growth factor-α and endocrine sensitivity in breast cancer. Cancer Research 54 (7) , pp. 1684-1689.

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The expression of transforming growth factor-α (TGF-α) has been evaluated in 51 breast cancers of known responsiveness to endocrine therapy using immunohistochemistry. High levels of TGF-α were observed in 65% of tumors and showed no relationship with tumor estrogen receptor or epidermal growth factor receptor status or Ki67 immunostaining. TGF-α levels did, however, relate to the endocrine sensitivity of the disease, with unresponsive tumors frequently showing high levels of TGF-α immunoreactivity. This relationship was observed in estrogen receptor-positive disease and was independent of the epidermal growth factor receptor status of the tumor. No quantitative association between TGF-α and Ki67 immunostaining was observed in any of the subcategories of tumors. These data infer a role for TGF-α in the development of endocrine insensitivity in estrogen receptor-positive breast cancer by mechanisms which appear independent of tumor growth fraction, as determined by Ki67 immunostaining.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
Publisher: American Association for Cancer Research
ISSN: 0008-5472
Last Modified: 12 Jun 2019 02:09

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