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Synthesis of Some Hydrazones and Osazones Containing Bromoquinazolines As Biologically Active Compounds

Abdel-Megeed, Mohamed F., El-Hiti, Gamal A. and Zied, Tarek M. 2001. Synthesis of Some Hydrazones and Osazones Containing Bromoquinazolines As Biologically Active Compounds. Delta Journal of Science 25 (1) , pp. 32-38.

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Abstract

Condensation of 6-bromo-4-hydrazinoquinazoline (1) and 6,8- dibromo-4-hydrazinoquinazoline (2) with equimolar amounts of monosaccharides (3) afforded the corresponding hydrazones 4-11 in good yields that on acetylation gave the corresponding acetyl derivatives 12-19. However, reaction of three molar equivalent amounts of 1 and 2 with 3 afforded the corresponding osazones 20-27 in fair yields that on acetylation gave the corresponding acetyl derivatives 28-35. Some of the synthesized compounds have been proved to be biologically active as anticancer reagents.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Faculty of Science, University of Tanta
ISSN: 1012-5965
Last Modified: 19 Mar 2016 22:26
URI: http://orca-mwe.cf.ac.uk/id/eprint/16380

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