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Synthesis and antimicrobial activities of novel sugar (2-phenylquinazolin-4-yl)hydrazones and their osazones

El-Hiti, Gamal A., Abdel-Megeed, Mohamed F. and Mahmoud, Yehia A.-G. 2000. Synthesis and antimicrobial activities of novel sugar (2-phenylquinazolin-4-yl)hydrazones and their osazones. Indian Journal of Chemistry Section B 39B (5) , pp. 368-376. 10.1002/chin.200103194

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Condensation of equimolar amounts of 4-hydrazino-2-phenylquinazoline 1 and a number of monosaccharides 2 (D-glucose, D-galactose, D-xylose, D-arabinose and D-ribose) affords the corresponding hydrazones 3-7 in good yields. However, whem three molar equivalents of 1 is allowed to react with 2 in the presence of glacial acetic acid, the corresponding osazones 13-16 are obtained. Acetylation of the hydrazones 3-7 and osazones 13-16 give the corresponding acetyl derivatives 8-12 and 17-20. The products obtained have been characterised by spectral data and elemental analyses. Some of the compounds show antifungal and antibacterial activities.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Publications & Information Directorate, Csir / NISCAIR
ISSN: 0376-4699
Last Modified: 19 Mar 2016 22:25

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