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Synthesis and reactions of some 3 aryl-2-thioxoquinazolin-4(3H)-ones

El-Hiti, Gamal A., Abdel-Megeed, Mohamed F. and Zied, Tarek M. M. 2002. Synthesis and reactions of some 3 aryl-2-thioxoquinazolin-4(3H)-ones. Indian Journal of Chemistry Section B 41B , pp. 1519-1522. 10.1002/chin.200243189

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A series of 3-aryl-2-thioxoquinazolin-4(3H)-ones 1a-g are prepared in good yields from reactions are prepared in good yields from reactions of anthranilic acids, aromatic amines and carbon disulfide under basic conditions in one step. Reaction of aminophenyl derivatives 1a,b with D-glucose affords the corresponding N-glucosylamines 4a,b in very good yields. Diaztoziation of 1a,b followed by reactions with aromatic amines yield the corresponding azo dyes 6a-f in 40-56% yields. The fastness of 6 has been studied. Compounds 6a,b,f have been proved to be biologically active.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Publications & Information Directorate, Csir / NISCAIR
ISSN: 0376-4699
Last Modified: 19 Mar 2016 22:25

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