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Muscarinic receptor agonists and antagonists

Broadley, Kenneth John and Kelly, David R. 2001. Muscarinic receptor agonists and antagonists. Molecules 6 (3) , pp. 142-193. 10.3390/60300142

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Abstract

A comprehensive review of pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists is presented. The therapeutic benefits of achieving receptor subtype selectivity are outlined and applications in the treatment of Alzheimer’s disease are discussed. A selection of chemical routes are described, which illustrate contemporary methodology for the synthesis of chiral medicinal compounds (asymmetric synthesis, chiral pool, enzymes). Routes to bicyclic intrannular amines and intramolecular Diels-Alder reactions are highlighted.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Uncontrolled Keywords: Alzheimer’s disease; nicotine; acetylcholine; arecoline; himbacine; tacrine; cyclostelletamines; intramolecular Diels-Alder reaction; indole alkaloids
Additional Information: Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1420-3049/ (accessed 20/02/2014).
Publisher: MDPI AG
ISSN: 1420-3049
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 03:01
URI: http://orca-mwe.cf.ac.uk/id/eprint/15394

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