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A convenient one step procedure for the formation of 2-substituted thiazolopyridines

El-Hiti, Gamal A. 2003. A convenient one step procedure for the formation of 2-substituted thiazolopyridines. Monatshefte für Chemie 134 (6) , pp. 837-841. 10.1007/s00706-002-0557-9

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2-Substituted thiazolo[4,5-b]pyridines and thiazolo[5,4-c]pyridines are prepared in reasonable yields by a one step procedure involving reaction of a mixture of ortho-amino(diisopropyldithiocarbamato)pyridine, carboxylic acid and phosphorus oxychloride. The procedure provides a much more convenient route than methods involving prior formation and isolation of acid amide that cyclised to give the desired products. The procedure is proved to be general for a wide range of substituents.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Uncontrolled Keywords: Thiazolopyridines; Carboxylic acids; Phosphorus oxychloride; Amino (diisopropyldithiocarbamato) pyridines; Cyclisation
Publisher: Springer Verlag
ISSN: 0026-9247
Last Modified: 19 Mar 2016 22:24

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