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Clinical and Experimental Experiences of Graft-Induced Dyskinesia

Lane, Emma Louise 2011. Clinical and Experimental Experiences of Graft-Induced Dyskinesia. In: Brotchie, J., Bezard, E. and Jenner, P. eds. Pathophysiology, pharmacology and biochemistry of dyskinesia, International Review of Neurobiology, vol. 98. Kidlington, Oxford: Academic Press, pp. 173-186. (10.1016/B978-0-12-381328-2.00007-9)

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Abstract

Clinical trials evaluating transplantation of fetal tissue for the treatment of Parkinson's disease identified the unexpected side effect of abnormal movements in the ‘off’ l-DOPA state. Termed graft-induced dyskinesia (GID), various hypotheses have been put forward as to their cause but unfortunately the significant differences in clinical trial protocols and lack of a truly representative animal model has hindered the search for a conclusive basis for their appearance. Likely causative factors have been identified through careful examination of patient data and the use of amphetamine-induced dyskinesia in a rodent model of Parkinson's disease. New trials being planned in Europe hope to avoid GID, whilst maximizing on the functional benefit that can be afforded by this treatment approach but questions still remain as to the underlying mechanism.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Amphetamine; Fetal cell transplantation; 6-OHDA lesioned rat; Parkinson's disease
Publisher: Academic Press
ISBN: 9780123813282
Last Modified: 04 Jun 2017 02:57
URI: http://orca-mwe.cf.ac.uk/id/eprint/14635

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