Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Use of hand-held dynamometry in the evaluation of lower limb muscle strength in people with Huntington's disease

Busse, Monica, Hughes, G., Wiles, Charles Mark and Rosser, Anne Elizabeth 2008. Use of hand-held dynamometry in the evaluation of lower limb muscle strength in people with Huntington's disease. Journal of Neurology 255 (10) , pp. 1534-1540. 10.1007/s00415-008-0964-x

[img]
Preview
PDF - Published Version
Download (191kB) | Preview

Abstract

Purpose -Sub-clinical muscle involvement, including myopathic changes and mitochondrial dysfunction of skeletal muscle, has been reported in people with Huntington’s disease (HD). Muscle strength was evaluated using a hand-held dynamometer. Reliability and validity in people with HD were determined. Method - Isometric muscle strength of 6 lower limb muscle groups was measured in 20 people with HD and matched healthy controls. People with HD were evaluated with the Unified Huntington’s Disease Rating Scales (UHDRS). Within session reliability using intra-class correlation coefficients (ICC) was calculated. Discriminant and convergent validity was also evaluated. Results - UHDRS motor scores of people with HD ranged from 28 to 80. Reliability of strength testing was excellent (ICC 0.86 to 0.98). People with HD had on average about half the strength of healthy matched controls. UHDRS motor scores and strength scores were significantly correlated (convergent) providing a further indication of validity of strength testing. Conclusions- The hand-held dynamometer is a reliable and valid measurement tool to detect strength differences between people with HD and a matched control group. There is significant reduction in lower limb muscle strength in HD which does not appear to have been described previously.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
Healthcare Sciences
Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: muscle strength ; muscle weakness ; Huntington‘s Disease ; dynamometry ; reliability
Publisher: Springer
ISSN: 0340-5354
Date of First Compliant Deposit: 30 March 2016
Last Modified: 28 Jun 2019 02:43
URI: http://orca-mwe.cf.ac.uk/id/eprint/14469

Citation Data

Cited 41 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics