Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

RAD9, RAD24, RAD16 and RAD26 are required for the inducible nucleotide excision repair of UV-induced cyclobutane pyrimidine dimmers from the transcribed and non-transcribed regions of the Sacchoromyces cerevisiae MFA2 gene

Yu, Shirong, Teng, Yumin, Lowndes, Noel F. and Waters, Raymond 2001. RAD9, RAD24, RAD16 and RAD26 are required for the inducible nucleotide excision repair of UV-induced cyclobutane pyrimidine dimmers from the transcribed and non-transcribed regions of the Sacchoromyces cerevisiae MFA2 gene. Mutation Research/DNA Repair 485 (3) , pp. 229-236. 10.1016/S0921-8777(01)00061-1

Full text not available from this repository.

Abstract

In this study, the effect of a prior UV irradiation on the removal of cyclobutane pyrimidine dimers (CPDs) from the transcribed strand (TS) and non-transcribed strand (NTS) of the MFA2 gene in haploid Saccharomyces cerevisiae (S. cerevisiae) cells was investigated. In NER competent cells, the pre-irradiation with a dose of 20 J/m2 enhances the removal of CPDs induced by a second UV dose of 100 J/m2 in the TS and the NTS of MFA2 gene except for the CPDs in the region +258 to +298 in the NTS, where the enhanced repair was absent. No inducible repair was observed in rad9, rad24, rad16 and rad26 cells, indicating two checkpoint genes RAD9 and RAD24, the global repair gene RAD16 and the transcription coupled repair gene RAD26 are essential for inducible NER.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Sacchromyces cerevisiae; MFA2; Inducible repair; Nucleotide excision repair; Cyclobutane pyrimidine dimers
ISSN: 0921-8777
Last Modified: 04 Jun 2017 01:30
URI: http://orca-mwe.cf.ac.uk/id/eprint/143

Actions (repository staff only)

Edit Item Edit Item