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Transparent, tough collagen laminates prepared by oriented flow casting, multi-cyclic vitrification and chemical cross-linking

Tanaka, Yuji, Babac, Koichi, Duncan, Thomas, Kubota, Akira, Asahif, Toru, Quantock, Andrew, Yamatob, Masayuki, Okanob, Teruo and Nishida, Kohji 2011. Transparent, tough collagen laminates prepared by oriented flow casting, multi-cyclic vitrification and chemical cross-linking. Biomaterials 32 (13) , pp. 3358-3366. 10.1016/j.biomaterials.2010.11.011

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Abstract

The lamellar architecture found in many natural fibrous tissues has a significant bearing on their specific functions. However, current engineered tissues have simultaneously no realistic structures and no adequate functions. This study demonstrates a two-step process for obtaining structurally mimicking laminates in natural fibrous tissues with good optical and mechanical characters from purified-clinically-safe collagen molecules. Stacked lamella structures can be created by repeating flow casting, with the controlling parallel/orthogonal directionalities of each thin single-layer (2–5 μm in thickness). The transparency of laminates is successfully improved by a unique multi-cyclic vitrification with chemical cross-linking. The directionalities of optical and mechanical functions in laminates are strongly related with the preferential collagen alignments in the laminates. The tensile strength of laminates is extremely higher than any other engineered materials as well as native cornea, which exhibit an orthogonal laminated collagen structure and a good optical transmission.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Uncontrolled Keywords: Collagen structure; Biomimetic material; Fibrous tissue; Biofilm; Soft tissue biomechanics; Cornea
Publisher: Elsevier
Last Modified: 04 Jun 2017 02:56
URI: http://orca-mwe.cf.ac.uk/id/eprint/14203

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