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Genomic imprinting on the X chromosome: implications for brain and behavioral phenotypes

Davies, William 2010. Genomic imprinting on the X chromosome: implications for brain and behavioral phenotypes. Annals of the New York Academy of Sciences 1204 (s1) , pp. 14-19. 10.1111/j.1749-6632.2010.05567.x

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Abstract

Imprinted genes, in contrast to most mammalian genes, are monoallelically expressed in a parent-of-origin dependent manner. The idiosyncratic expression profile associated with imprinted genes arises from the differential epigenetic marking of the alleles in the paternal and maternal germlines. Although small in number, imprinted genes can profoundly influence key developmental and physiological processes, including those in the brain; work in animal models and in humans has shown that such genes can affect behavioral traits and cognition and may confer vulnerability to common mental illnesses. As a consequence of how the X chromosome is inherited, X-linked imprinting may elicit or indeed attenuate sexually dimorphic phenotypes. Thus, studying X-linked imprinting is likely to provide important general information about the evolutionary and mechanistic underpinnings of imprinting, as well as the molecular processes underlying sex-specific neurobiology and sex-biased vulnerability to psychiatric disorders.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Uncontrolled Keywords: autism;epigenetic; imprinted genes; Rhox5; sexual dimorphism; Turner syndrome; 39, XO mouse; X-inactivation; Xlr
Additional Information: Issue: Epigenetics and Neuropsychiatric Diseases
Publisher: Wiley-Blackwell
ISSN: 0077-8923
Last Modified: 24 Apr 2019 13:47
URI: http://orca-mwe.cf.ac.uk/id/eprint/13777

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