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No genetic overlap between circulating iron levels and Alzheimer's disease

Lupton, Michelle K., Benyamin, Beben, Proitsi, Petroula, Nyholt, Dale R., Ferreira, Manuel A., Montgomery, Grant W., Heath, Andrew C., Madden, Pamela A., Medland, Sarah E., Gordon, Scott D., GERAD1 Consortium, , Alzheimer's Disease neuroimaging Initiative, , Lovestone, Simon, Tsolaki, Magda, Kloszewska, Iwona, Soininen, Hilkka, Mecocci, Patrizia, Vellas, Bruno, Powell, John F., Bush, Ashley I., Wright, Margaret J., Martin, Nicholas G., Whitfield, John B. and Williams, Julie 2017. No genetic overlap between circulating iron levels and Alzheimer's disease. Journal of Alzheimer's Disease 59 (1) , pp. 85-99. 10.3233/JAD-170027

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Abstract

Iron deposition in the brain is a prominent feature of Alzheimer’s disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: Julie Williams is a member of the GERAD1 Consortium
Publisher: IOS Press
ISSN: 1387-2877
Date of Acceptance: 20 April 2017
Last Modified: 27 Oct 2020 15:00
URI: http://orca-mwe.cf.ac.uk/id/eprint/135938

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