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A radiation hybrid map of the rat genome containing 5,255 markers

Watanabe, Takeshi K., Bihoreau, Marie-Therese, McCarthy, Linda C., Kiguwa, Susanna L., Hishigaki, Haretsugu, Tsuji, Atsushi, Browne, Julie, Yamasaki, Yuki, Mizoguchi-Miyakita, Ayako, Oga, Keiko, Ono, Toshihide, Okuno, Shiro, Kanemoto, Naohide, Takahashi, Ei-ichi, Tomita, Kazuhiro, Hayashi, Hiromi, Adachi, Masakazu, Webber, Caleb, Davis, Marie, Kiel, Susanne, Knights, Catherine, Smith, Angela, Critcher, Ricky, Miller, Jonathan, Thangarajah, Thiru, Day, Philip J. R., Hudson Jr., James R., Irie, Yasuo, Takagi, Toshihisa, Nakamura, Yusuke, Goodfellow, Peter N., Lathrop, G. Mark, Tanigami, Akira and James, Michael R. 1999. A radiation hybrid map of the rat genome containing 5,255 markers. Nature Genetics 22 , pp. 27-36. 10.1038/8737

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Abstract

A whole-genome radiation hybrid (RH) panel was used to construct a high-resolution map of the rat genome based on microsatellite and gene markers. These include 3,019 new microsatellite markers described here for the first time and 1,714 microsatellite markers with known genetic locations, allowing comparison and integration of maps from different sources. A robust RH framework map containing 1,030 positions ordered with odds of at least 1,000:1 has been defined as a tool for mapping these markers, and for future RH mapping in the rat. More than 500 genes which have been mapped in mouse and/or human were localized with respect to the rat RH framework, allowing the construction of detailed rat-mouse and rat-human comparative maps and illustrating the power of the RH approach for comparative mapping.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Nature
ISSN: 1061-4036
Date of Acceptance: 25 March 1999
Last Modified: 23 Oct 2020 14:00
URI: http://orca-mwe.cf.ac.uk/id/eprint/135809

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