Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Headache and type 2 diabetes association: a US national ambulatory case-control study

Nash, Anthony, Holgado, Alejo J. Nevado, Lovestone, Simon, Cader, M. Zameel and Webber, Caleb 2018. Headache and type 2 diabetes association: a US national ambulatory case-control study. bioRxiv 10.1101/336586

[img] PDF (Licensed under CC-BY-NC-ND 4.0) - Submitted Pre-Print Version
Download (92kB)

Abstract

Objective We investigate the joint observation between type 2 diabetes and headache using a case-control study of a US ambulatory dataset. Background Recent whole-population cohort studies propose that type 2 diabetes may have a protective effect against headache prevalence. With headaches ranked as a leading cause of disability, headache-associated comorbidities could help identify shared molecular mechanisms. Methods We performed a case-control study using the US National Ambulatory Medical Care Survey, 2009, on the joint observation between headache and specific comorbidities, namely type 2 diabetes, hypertension and anxiety, for all patients between 18 and 65 years of age. The odds ratio of having a headache and a comorbidity were calculated using conditional logistic regression, controlling for gender and age over a study population of 3,327,947 electronic health records in the absence of prescription medication data. Results We observed estimated odds ratio of 0.89 (95% CI: 0.83-0.95) of having a headache and a record of type 2 diabetes over the population, and 0.83 (95% CI: 2.02-2.57) and 0.89 (95% CI: 3.00-3.49) for male and female, respectively. Conclusions We find that patients with type 2 diabetes are less likely to present a recorded headache indication. Patients with hypertension are almost twice as likely of having a headache indication and patients with an anxiety disorder are almost three times as likely. Given the possibility of confounding indications and prescribed medications, additional studies are recommended.

Item Type: Article
Date Type: Published Online
Status: Submitted
Schools: Medicine
Publisher: Cold Spring Harbor Laboratory
Last Modified: 25 Nov 2020 20:46
URI: http://orca-mwe.cf.ac.uk/id/eprint/135770

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics