Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Global immunoglobulin supply: steaming towards the iceberg?

Prevot, Johan and Jolles, Stephen 2020. Global immunoglobulin supply: steaming towards the iceberg? Current Opinion in Allergy and Clinical Immunology 20 (6) , pp. 557-564. 10.1097/ACI.0000000000000696
Item availability restricted.

[img] PDF - Accepted Post-Print Version
Restricted to Repository staff only until 9 October 2021 due to copyright restrictions.
Available under License Creative Commons Attribution Non-commercial.

Download (276kB)

Abstract

Purpose of review This review describes how plasma is sourced for fractionation into plasma-derived medicinal products (PDMPs), such as immunoglobulin (Ig) together with differences between plasma from whole blood (recovered plasma) and from plasmapheresis (source plasma) in terms of global plasma supply. Specific areas of growth in immunoglobulin use are identified alongside novel therapies, which may reduce demand for some immunoglobulin indications. Recent findings There has been a 6--8% annual growth in immunoglobulin use. Secondary immunodeficiency alongside improved recognition and diagnosis primary immunodeficiency disorders are drivers whereas the novel neonatal Fc receptor inhibitors (FcRni) may reduce demand for some immunomodulatory indications. Summary There is a significant geographical imbalance in global supply of plasma with 65% collected in the United States. This results in a dependency of other countries on United States supply and argues for both more plasma supply and greater regionally balanced plasma collection. In addition, progress towards a transparent, regulated and well tolerated framework for the coexistence of unpaid and compensated plasma donations is needed as unpaid donation will not be sufficient. These discussions should be informed by the needs of patients for this life-saving therapy, the care of donors and the safety of plasma and PDMPs.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Lippincott, Williams & Wilkins
ISSN: 1528-4050
Date of First Compliant Deposit: 16 October 2020
Date of Acceptance: 17 September 2020
Last Modified: 03 Dec 2020 13:36
URI: http://orca-mwe.cf.ac.uk/id/eprint/135606

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics