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LRIK interacts with the Ku70–Ku80 heterodimer enhancing the efficiency of NHEJ repair

Wang, Dan, Zhou, Zheng, Wu, Erzhong, Ouyang, Can, Wei, Guifeng, Wang, Yunfei, He, Dandan, Cui, Ya, Zhang, Dongdong, Chen, Xiaomin, Reed, Simon H., Luo, Jianjun and Chen, Runsheng 2020. LRIK interacts with the Ku70–Ku80 heterodimer enhancing the efficiency of NHEJ repair. Cell Death and Differentiation 10.1038/s41418-020-0581-5

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Abstract

Despite recent advances in our understanding of the function of long noncoding RNAs (lncRNAs), their roles and functions in DNA repair pathways remain poorly understood. By screening a panel of uncharacterized lncRNAs to identify those whose transcription is induced by double-strand breaks (DSBs), we identified a novel lncRNA referred to as LRIK that interacts with Ku, which enhances the ability of the Ku heterodimer to detect the presence of DSBs. Here, we show that depletion of LRIK generates significantly enhanced sensitivity to DSB-inducing agents and reduced DSB repair efficiency. In response to DSBs, LRIK enhances the recruitment of repair factors at DSB sites and facilitates γH2AX signaling. Our results demonstrate that LRIK is necessary for efficient repairing DSBs via nonhomologous end-joining pathway.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Medicine
Publisher: Nature Publishing Group
ISSN: 1350-9047
Date of First Compliant Deposit: 7 August 2020
Date of Acceptance: 12 June 2020
Last Modified: 10 Aug 2020 15:45
URI: http://orca-mwe.cf.ac.uk/id/eprint/134042

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