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The role of SIPA1 in the development of cancer and metastases (Review)

Liu, Chang, Jiang, Wen, Hargest, Rachel and Martin, Tracey 2020. The role of SIPA1 in the development of cancer and metastases (Review). Molecular and Clinical Oncology 13 (4) , 32. 10.3892/mco.2020.2102
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Abstract

Cancer is a leading cause of mortality and the majority of deaths are due to metastases. Many molecules have been implicated in the development of metastases. Signal induced proliferation associated protein 1 (SIPA1), a mitogen‑inducible gene, has been demonstrated to be involved in the metastasis of various solid tumours and may indicate a poor prognosis. Polymorphisms of SIPA1 can be associated with several different types of cancer and interactions between SIPA1 and binding molecules integrate a series of cellular functions, which may promote the development and metastasis of cancer. The mechanisms by which SIPA1 promotes the development and metastasis of cancer varies among tumour types. The present review describes the structure, function and regulation of SIPA1 and focuses on its role in cancer metastasis. Possibilities for future research and the clinical application of SIPA1 are also discussed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Spandidos Publications
ISSN: 2049-9450
Date of First Compliant Deposit: 29 July 2020
Date of Acceptance: 16 June 2020
Last Modified: 05 Sep 2020 01:24
URI: http://orca-mwe.cf.ac.uk/id/eprint/133863

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