Concurrent recording of co-localized electroencephalography and local field potential in rodent

Kang, Sungmin ORCID: https://orcid.org/0000-0002-7442-4143, Bruyns-Haylett, Michael, Hayashi, Yurie and Zheng, Ying 2017. Concurrent recording of co-localized electroencephalography and local field potential in rodent. Journal of Visualized Experiments (129) , e56447. 10.3791/56447

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Abstract

Although electroencephalography (EEG) is widely used as a non-invasive technique for recording neural activities of the brain, our understanding of the neurogenesis of EEG is still very limited. Local field potentials (LFPs) recorded via a multi-laminar microelectrode can provide a more detailed account of simultaneous neural activity across different cortical layers in the neocortex, but the technique is invasive. Combining EEG and LFP measurements in a pre-clinical model can greatly enhance understanding of the neural mechanisms involved in the generation of EEG signals, and facilitate the derivation of a more realistic and biologically accurate mathematical model of EEG. A simple procedure for acquiring concurrent and co-localized EEG and multi-laminar LFP signals in the anesthetized rodent is presented here. We also investigated whether EEG signals were significantly affected by a burr hole drilled in the skull for the insertion of a microelectrode. Our results suggest that the burr hole has a negligible impact on EEG recordings.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Psychology
Publisher:	Journal of Visualized Experiments (JoVE)
ISSN:	1940-087X
Date of First Compliant Deposit:	30 June 2020
Last Modified:	05 May 2023 10:29
URI:	https://orca.cardiff.ac.uk/id/eprint/132890

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