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Selective hydroboration - oxidation of terminal alkenes under flow conditions

Elsherbini, Mohamed, Huynh, Florence, Dunbabin, Alice, Allemann, Rudolf and Wirth, Thomas 2020. Selective hydroboration - oxidation of terminal alkenes under flow conditions. Chemistry - A European Journal 10.1002/chem.202001650

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Abstract

Abstract An efficient flow process for the selective hydroboration and oxidation of different alkenes using 9‐BBN allows facile conversion in high productivity (1.4 g/h) of amorpha‐4,11‐diene to the corresponding alcohol, which is an advanced intermediate in the synthesis of the antimalarial drug artemisinin. The in situ reaction of borane and 1,5‐cyclooctadiene using a simple flow generator proved to be a cost efficient solution for the generation of 9‐BBN.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Chemistry
Publisher: Wiley
ISSN: 0947-6539
Funders: Bills and Melinda Gates Foundation
Date of First Compliant Deposit: 16 June 2020
Date of Acceptance: 22 April 2020
Last Modified: 06 Aug 2020 15:08
URI: http://orca-mwe.cf.ac.uk/id/eprint/132477

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