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The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions

Mitra, Anita, MacIntyre, David A., Ntritsos, George, Smith, Ann, Tsilidis, Konstantinos K., Marchesi, Julian R., Bennett, Phillip R., Moscicki, Anna-Barbara and Kyrgiou, Maria 2020. The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions. Nature Communications 11 (1) , 1999. 10.1038/s41467-020-15856-y

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Abstract

Emerging evidence suggests associations between the vaginal microbiota (VMB) composition, human papillomavirus (HPV) infection, and cervical intraepithelial neoplasia (CIN); however, causal inference remains uncertain. Here, we use bacterial DNA sequencing from serially collected vaginal samples from a cohort of 87 adolescent and young women aged 16–26 years with histologically confirmed, untreated CIN2 lesions to determine whether VMB composition affects rates of regression over 24 months. We show that women with a Lactobacillus-dominant microbiome at baseline are more likely to have regressive disease at 12 months. Lactobacillus spp. depletion and presence of specific anaerobic taxa including Megasphaera, Prevotella timonensis and Gardnerella vaginalis are associated with CIN2 persistence and slower regression. These findings suggest that VMB composition may be a future useful biomarker in predicting disease outcome and tailoring surveillance, whilst it may offer rational targets for the development of new prevention and treatment strategies.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Biosciences
Publisher: Nature Research
ISSN: 2041-1723
Date of First Compliant Deposit: 5 May 2020
Date of Acceptance: 12 March 2020
Last Modified: 06 May 2020 09:30
URI: http://orca-mwe.cf.ac.uk/id/eprint/131467

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