Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Characterisation of EphA1 and its potential role in Alzheimer’s Disease

Owens, Helen Anne 2019. Characterisation of EphA1 and its potential role in Alzheimer’s Disease. PhD Thesis, Cardiff University.
Item availability restricted.

[thumbnail of Owens, Helen 0709192 Corrected thesis.pdf]
Preview
PDF - Accepted Post-Print Version
Download (6MB) | Preview
[thumbnail of Cardiff University Electronic Publication Form] PDF (Cardiff University Electronic Publication Form) - Supplemental Material
Restricted to Repository staff only

Download (176kB)

Abstract

Recent genetic evidence has identified the EphA1 gene as a susceptibility locus in Alzheimer’s disease with targeted sequencing identifying a nonsynonymous variant (P460L) within intron 1 (Vardarajan et al., 2015). EphA1 encodes the type-I transmembrane protein EphA1, a member of the Eph family of receptor tyrosine kinases. Eph receptors and their surface associated ligands, ephrins, play a role in immunity and inflammation, with inflammatory mechanisms a central component of AD neuropathology. This study aimed to characterise the WT EphA1 molecule as a means to understand the pathological potential of P460L EphA1.

Item Type: Thesis (PhD)
Date Type: Completion
Status: Unpublished
Schools: Medicine
Date of First Compliant Deposit: 12 February 2020
Last Modified: 26 Mar 2021 16:13
URI: https://orca.cardiff.ac.uk/id/eprint/129570

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics