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Neurotransmitter, antioxidant and anti-neuroinflammatory mechanistic potentials of herbal medicines in ameliorating autism spectrum disorder

Kardani, Arefeh, Soltani, Amin, Sewell, Robert D.E., Shahrani, Mehrdad and Rafieian-Kopaei, Mahmoud 2019. Neurotransmitter, antioxidant and anti-neuroinflammatory mechanistic potentials of herbal medicines in ameliorating autism spectrum disorder. Current Pharmaceutical Design 25 (41) , pp. 4421-4429. 10.2174/1381612825666191112143940

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Abstract

Background: Autism spectrum disorder (ASD) is a neurodevelopmental issue that disrupts behavior, nonverbal communication, and social interaction, impacting all aspects of an individual’s social development. The underlying origin of autism is unclear, however, oxidative stress, as well as serotonergic, adrenergic and dopaminergic systems are thought to be implicated in ASD. Despite the fact that there is no effective medication for autism, current pharmacological treatments are utilized to ameliorate some of the symptoms such as selfmutilation, aggression, repetitive and stereotyped behaviors, inattention, hyperactivity, and sleep disorders. Methods: In accord with the literature regarding the activity of herbal medicines on neurotransmitter function, we aimed to review the most worthy medicinal herbs possessing neuroprotective effects. Results: Based on the outcome, medicinal herbs such as Zingiber officinale, Astragalus membranaceu, Ginkgo biloba, Centella asiatica and Acorus calamus, have antioxidant activity, which can influence neurotransmitter systems and are potentially neuroprotective. Conclusion: Consequently, these herbs, in theory at least, appear to be suitable candidates within an overall management strategy for those on the autism spectrum.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Pharmacy
Publisher: Bentham Science Publishers
ISSN: 1381-6128
Date of First Compliant Deposit: 31 January 2020
Date of Acceptance: 9 November 2019
Last Modified: 10 Mar 2020 22:17
URI: http://orca-mwe.cf.ac.uk/id/eprint/129230

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