Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth

Hayes, Mark David, Ward, Sophie, Crawford, Greg, Seoane, Rocio Castro, Jackson, William David, Kipling, David, Voehringer, David, Dunn-Walters, Deborah and Strid, Jessica 2020. Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth. eLife 9 , e51862. 10.7554/eLife.51862

PDF - Published Version
Available under License Creative Commons Attribution.

Download (3MB) | Preview


IgE is the least abundant circulating antibody class but is constitutively present in healthy tissues bound to resident cells via its high-affinity receptor, FcεRI. The physiological role of endogenous IgE antibodies is unclear but it has been suggested that they provide host protection against a variety of noxious environmental substances and parasitic infections at epithelial barrier surfaces. Here we show, in mice, that skin inflammation enhances levels of IgE antibodies that have natural specificities and a repertoire, VDJ rearrangements and CDRH3 characteristics similar to those of IgE antibodies in healthy tissue. IgE-bearing basophils are recruited to inflamed skin via CXCL12 and thymic stromal lymphopoietin (TSLP)/IL-3-dependent upregulation of CXCR4. In the inflamed skin, IgE/FcεRI-signalling in basophils promotes epithelial cell growth and differentiation, partly through histamine engagement of H1R and H4R. Furthermore, this IgE response strongly drives tumour outgrowth of epithelial cells harbouring oncogenic mutation. These findings indicate that natural IgE antibodies support skin barrier defences, but that during chronic tissue inflammation this role may be subverted to promote tumour growth.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: eLife Sciences Publications
ISSN: 2050-084X
Date of First Compliant Deposit: 28 January 2020
Date of Acceptance: 18 December 2019
Last Modified: 29 Jan 2020 11:00

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics