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ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells

Jimenez-Pascual, Ana, Lathia, Justin D. and Siebzehnrubl, Florian A. 2019. ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells. Molecular & Cellular Oncology 7 (1) , 1684787. 10.1080/23723556.2019.1684787

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Abstract

Identification of targetable mechanisms that maintain glioblastoma cancer stem cells (CSCs) remain a priority. Our study reveals a new mechanism by which a disintegrin and metalloproteinase domain-like protein decysin 1 promotes CSC maintenance through the activation of a fibroblast growth factor autocrine signaling loop, which can be blocked pharmacologically.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
ISSN: 2372-3556
Date of First Compliant Deposit: 13 January 2020
Date of Acceptance: 22 October 2019
Last Modified: 26 Nov 2020 08:30
URI: http://orca-mwe.cf.ac.uk/id/eprint/128458

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