Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Reduction of niridazole by metronidazole resistant and susceptible strains of Trichomonas vaginalis

Yarlett, N., Rowlands, C.C., Evans, J.C., Yarlett, N.C. and Lloyd, David 1987. Reduction of niridazole by metronidazole resistant and susceptible strains of Trichomonas vaginalis. Parasitology 94 (1) , pp. 93-99. 10.1017/S0031182000053488

Full text not available from this repository.

Abstract

The inhibitory effect of niridazole on hydrogen production by metronidazole-resistant (CDC-85) and susceptible (Cl-NIH) Trichomonas vaginalis strains was investigated. The results show that niridazole is more effective than metronidazole in inhibiting hydrogen production by the resistant isolate. In CDC-85 aerobic inhibition requires a 4-fold increase in metronidazole concentration compared with that required anaerobically, but the corresponding factor for niridazole is only 1·5-fold. Reduction of the drug by a hydrogenosome-enriched preparation gave rise to a multiline electron spin resonance detectable signal, which is due to a nitrogen-centred radical.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Cambridge University Press (CUP)
ISSN: 0031-1820
Last Modified: 20 Feb 2020 13:30
URI: http://orca-mwe.cf.ac.uk/id/eprint/128062

Actions (repository staff only)

Edit Item Edit Item