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Effects of inhibitors on mitochondrial adenosine triphosphatase of Crithidia fasciculata: an unusual pattern of specificities

Yarlett, Nigel and Lloyd, David 1981. Effects of inhibitors on mitochondrial adenosine triphosphatase of Crithidia fasciculata: an unusual pattern of specificities. Molecular and Biochemical Parasitology 3 (1) , 13--17. 10.1016/0166-6851(81)90073-6

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Abstract

The mitochondrial adenosine triphosphatase of the kinetoplastid protozoon, Crithidia fasciculata, is inhibited by oligomycin, venturicidin, triethyltin sulphate, N,N′-dicyclohexylcarbodiimide, leucinostatin, Dio-9 and quercetin, but not by spegazzinine or by compounds which interact with the β- subunit of mitochondrial F1-ATPase (efrapeptin, aurovertin, citreoviridin or 4-chloro-7-nitrobenzofurazan). These results suggest that the F1 portion of the crithidial enzyme has an unusual type of β- subunit. Further evidence for the atypical nature of this enzyme is provided by the observation that F1-inhibitor proteins from Acanthamoeba castellanii or bovine heart mitochondria do not inhibit the C. fasciculata enzyme activity

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0166-6851
Date of Acceptance: 10 September 1980
Last Modified: 20 Feb 2020 15:45
URI: http://orca-mwe.cf.ac.uk/id/eprint/128059

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