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A simple and convenient high yielding synthesis of substituted isoindolines

Smith, Keith, El-Hiti, Gamal A., Hegazy, Amany Saber and Shalabi, Ahmed Fekri 2010. A simple and convenient high yielding synthesis of substituted isoindolines. Heterocycles 80 (2) , pp. 941-956. 10.3987/COM-09-S(S)61

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Abstract

Trifluoroacetic anhydride-induced dehydration of substituted 2-(pivaloylaminomethyl)phenyl- and 2-(dimethylaminocarbonylmethyl)phenylmethanols gives the corresponding isoindolines in excellent yields when there are aryl substituents at the methanol carbon atom.

Item Type: Article
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Uncontrolled Keywords: Cyclization ; Dehydration ; Heterocycle ; Substituted Benzyl-N,N-dimethylurea ; Synthesis
Publisher: Sendai Institute of Heterocyclic Chemistry
ISSN: 0385-5414
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 02:51
URI: http://orca-mwe.cf.ac.uk/id/eprint/12724

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