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Antibodies to glutamate reversed the amnesic effects of proinflammatory S100A9 protein fibrils in aged C57Bl/6 mice

Gruden, M. A, Davydova, T. V, Fomina, V. G, Vetrile, L. A, Morozova-Roche, L. A and Sewell, Robert 2017. Antibodies to glutamate reversed the amnesic effects of proinflammatory S100A9 protein fibrils in aged C57Bl/6 mice. Bulletin of Experimental Biology and Medicine 162 (4) , pp. 430-432. 10.1007/s10517-017-3632-2

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Abstract

Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: amnesia; S100A9 fibrils; glutamate antibodies; spatial memory; locomotor
Publisher: Springer Verlag (Germany)
ISSN: 0007-4888
Date of First Compliant Deposit: 22 October 2019
Date of Acceptance: 26 October 2016
Last Modified: 10 Mar 2020 23:25
URI: http://orca-mwe.cf.ac.uk/id/eprint/126190

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