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Fine tuning T lymphocytes: a role for the lipid phosphatase SHIP-1.

Parry, Richard V., Harris, Stephanie J. and Ward, Stephen G. 2010. Fine tuning T lymphocytes: a role for the lipid phosphatase SHIP-1. Biochimica et Biophysica Acta 1804 (3) , pp. 529-597. 10.1016/j.bbapap.2009.09.019

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The phosphoinositide 3-kinase signaling pathway regulates a range of T lymphocyte cellular functions including growth, proliferation, cytokine secretion and survival. Aberrant regulation of phosphoinositide 3-kinase-dependent signaling in T lymphocytes has been implicated in inflammatory and autoimmune diseases. In common with much of the immune system, several mechanisms exist to ensure the pathway is tightly regulated to elicit appropriate responses. One level of control involves the Src homology 2 domain-containing inositol-5-phosphatase-1 (SHIP-1) that modulates phosphoinositide 3-kinase signaling by degrading the key signaling lipid PI(3,4,5)P3 to PI(3,4)P2, but also serves as a key scaffolding molecule in the formation of multi-protein complexes. Here we discuss the role of SHIP-1 in regulating T lymphocyte and immune function, as well as its potential as a therapeutic target.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 0006-3002
Last Modified: 17 Jan 2020 12:22

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