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Medicinal plants with multiple effects on Diabetes Mellitus and its complications: A systematic review

Nazarian-Samani, Zeinab, Sewell, Robert, Lorigooini, Zahra and Rafieian-Kopaei, Mahmoud 2018. Medicinal plants with multiple effects on Diabetes Mellitus and its complications: A systematic review. Current Diabetes Reports 18 (10) , p. 72. 10.1007/s11892-018-1042-0

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Purpose of Review This systematic review describes evidence concerning medicinal plants that, in addition to exerting hypoglycemic effects, decrease accompanying complications such as nephropathy, neuropathy, retinopathy, hypertension and/or hyperlipidemia. Recent Findings Studies on the antidiabetic mechanisms of medicinal plants have shown that most of them produce hypoglycemic activity by: stimulating insulin secretion, augmenting peroxisome proliferator-activated receptors (PPARs), inhibiting α-amylase or α-glucosidase, inhibiting the secretion of glucagon-like peptide-1 (GLP-1), inhibiting advanced glycation end product (AGE) formation, free radical scavenging plus antioxidant activity (against reactive oxygen- or nitrogen- species: ROS/RNS) up-regulating or elevating translocation of glucose transporter type 4 (GLUT-4) and preventing development of insulin resistance. Summary Not only are medicinal plants effective in diabetes mellitus, but many of them also possess a variety of effects on other disease states, including the complications of diabetes. Such plants may be appropriate alternatives or adjuncts to available antidiabetic medications.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Diabetes mellitus, Medicinal plants, Nephropathy, Neuropathy
Publisher: Current Medicine Group
ISSN: 1534-4827
Funders: unspecified
Date of First Compliant Deposit: 30 September 2019
Date of Acceptance: 13 August 2018
Last Modified: 18 Oct 2019 06:53

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